Aircraft were used for reconnaissance, as fighters, bombers, and ground-support, and each role was advanced considerably. Innovation included airlift (the capability to quickly move limited high-priority supplies, equipment, and personnel); and of strategic bombing (the bombing of enemy industrial and population centres to destroy the enemy's ability to wage war). The use of the jet aircraft was pioneered and, though late introduction meant it had little impact, it led to jets becoming standard in air forces worldwide.

Advances were made in nearly every aspect of naval warfare, most notably with aircraft carriers and submarines. Although aeronautical warfare had relatively little success at the start of the war, actions at Taranto, Pearl Harbor, and the Coral Sea established the carrier as the dominant capital ship in place of the battleship. Submarines, which had proved to be an effective weapon during the First World War, were anticipated by all sides to be important in the second. The British focused development on anti-submarine weaponry and tactics, such as sonar and convoys, while Germany focused on improving its offensive capability, with designs such as the Type VII submarine and wolfpack tactics. Gradually, improving Allied technologies such as the Leigh light, hedgehog, squid, and homing torpedoes proved victorious over the German submarines.

Land warfare changed from the static front lines of trench warfare of World War I, which had relied on improved artillery that outmatched the speed of both infantry and cavalry, to increased mobility and combined arms. The tank, which had been used predominantly for infantry support in the First World War, had evolved into the primary weapon.

Most major belligerents attempted to solve the problems of complexity and security involved in using large codebooks for cryptography by designing ciphering machines, the most well known being the German Enigma machine. Development of SIGINT (signals intelligence) and cryptanalysis enabled the countering process of decryption.

Other technological and engineering feats achieved during, or as a result of, the war include the world's first programmable computers (Z3, Colossus, and ENIAC), guided missiles and modern rockets, the Manhattan Project's development of nuclear weapons, operations research and the development of artificial harbours and oil pipelines under the English Channel. Penicillin was first mass-produced and used during the war.