The Fall of Acre took place in 1291 and resulted in the Crusaders losing control of Acre to the Mamluks. It is considered one of the most important battles of the period. Although the crusading movement continued for several more centuries, the capture of the city marked the end of further crusades to the Levant. When Acre fell, the Crusaders lost their last major stronghold of the Crusader Kingdom of Jerusalem. They still maintained a fortress at the northern city of Tartus (today in north-western Syria), engaged in some coastal raids, and attempted an incursion from the tiny island of Ruad, but when they lost that as well in 1302 in the siege of Ruad, the Crusaders no longer controlled any part of the Holy Land.

The fall of Acre signaled the end of the Jerusalem crusades. No effective crusade was raised to recapture the Holy Land afterwards, though talk of further crusades was common enough. By 1291, other ideals had captured the interest and enthusiasm of the monarchs and nobility of Europe and even strenuous papal efforts to raise expeditions to retake the Holy Land met with little response. The Latin Kingdom continued to exist, theoretically, on the island of Cyprus. There the Latin kings planned to recapture the mainland, but in vain. Money, men, and the will to do the task were all lacking. 

The Teutonic Knights accepted and surrendered their tower after being allowed to leave with their women, but al-Mansuri was killed by other Crusaders. Teutonic Knights headquarters moved from Acre to Venice.