The Ottoman–Safavid War of 1532–1555 was one of the many military conflicts fought between the two arch rivals, the Ottoman Empire led by Suleiman the Magnificent, and the Safavid Empire led by Tahmasp I.

The war was triggered by territorial disputes between the two empires, especially when the Bey of Bitlis decided to put himself under Persian protection. Also, Tahmasp had the governor of Baghdad, a sympathiser of Suleiman, assassinated. On the diplomatic front, Safavids had been engaged in discussions with the Habsburgs for the formation of a Habsburg–Persian alliance that would attack the Ottoman Empire on two fronts.