On 26 June 1745, the Republic of Genoa declared war on the Kingdom of Sardinia. This decision would prove disastrous for Genoa, which later surrendered to the Austrians in September 1746 and was briefly occupied before a revolt liberated the city two months later. The Austrians returned in 1747 and, along with a contingent of Sardinian forces, laid siege to Genoa before being driven off by the approach of a Franco-Spanish army.

Though Genoa retained its lands in the Peace of Aix-la-Chapelle, it was unable to keep its hold on Corsica in its weakened state. After driving out the Genoese, the Corsican Republic was declared in 1755. Eventually relying on French intervention to quash the rebellion, Genoa was forced to cede Corsica to the French in the 1768 Treaty of Versailles.