The Byzantine–Sasanian War of 602–628 was the final and most devastating of the series of wars fought between the Byzantine Empire and the Sasanian Empire of Iran. This became a decades-long conflict, the longest war in the series, and was fought throughout the Middle East: in Egypt, the Levant, Mesopotamia, the Caucasus, Anatolia, Armenia, the Aegean Sea and before the walls of Constantinople itself.

By the end of the conflict, both sides had exhausted their human and material resources and achieved very little. Consequently, they were vulnerable to the sudden emergence of the Islamic Rashidun Caliphate, whose forces invaded both empires only a few years after the war.