Wei Zhongxian was a Chinese court eunuch who lived in the late Ming dynasty. As a eunuch he used the name Li Jinzhong (李进忠). He is considered as the most notorious eunuch in Chinese history. He is best known for his service in the court of the Tianqi Emperor Zhu Youjiao (r. 1620–1627), when his power eventually appeared to rival that of the emperor. Mao Wenlong was one of the generals promoted by Wei Zhongxian. During Zhu Youjiao's reign, Wei would send the emperor's edicts to the Embroidered Uniform Guard led by prison director Xu Xianchun to purge corrupt officials and political enemies. Xu then arrested and demoted hundreds of officials and scholars from the Donglin movement, including Zhou Zongjian, Zhou Shunchang, and Yang Lian.

When Zhu Youjian rose to power, he received complaints about Wei and Xu's actions. Zhu Youjian then ordered the Embroidered Uniform Guard to arrest Wei Zhongxian. Wei then committed suicide.