On June 13, 1847, Commodore Perry assembled the Mosquito Fleet and began moving towards the Grijalva River, towing 47 boats that carried a landing force of 1,173. On June 15, 12 miles (19 km) below San Juan Bautista, the fleet ran through an ambush with little difficulty. Again at an "S" curve in the river known as the "Devil's Bend", Perry encountered Mexican fire from a river fortification known as the Colmena redoubt, but the fleet's heavy naval guns quickly dispersed the Mexican force.

On June 16, Perry arrived at San Juan Bautista and commenced bombing the city. The attack included two ships that sailed past the fort and began shelling it from the rear. David D. Porter led 60 sailors ashore and seized the fort, raising the American flag over the works. Perry and the landing force arrived and took control of the city around 14:00.