The Portuguese' monopolizing interventions were disrupting Indian Ocean trade, threatening Arab as well as Venetian interests, as it became possible for the Portuguese to undersell the Venetians in the spice trade in Europe. Venice broke diplomatic relations with Portugal and started to look at ways to counter its intervention in the Indian Ocean, sending an ambassador to the Egyptian court. Venice negotiated for Egyptian tariffs to be lowered to facilitate competition with the Portuguese, and suggested that "rapid and secret remedies" be taken against the Portuguese.

The Portuguese– Egyptian Mamluk Naval War was a naval conflict between the Egyptian state of the Mamluks and the Portuguese in the Indian Ocean, following the expansion of the Portuguese after sailing around the Cape of Good Hope in 1498. The conflict took place during the early part of the 16th century, from 1505 to the fall of the Mamluk Sultanate in 1517.