The fall of Ruad in 1302 was one of the culminating events of the Crusades in the Eastern Mediterranean. When the garrison on the tiny Isle of Ruad fell, it marked the loss of the last Crusader outpost on the coast of the Levant. In 1291, the Crusaders had lost their main power base at the coastal city of Acre, and the Muslim Mamluks had been systematically destroying any remaining Crusader ports and fortresses since then, forcing the Crusaders to relocate their dwindling Kingdom of Jerusalem to the island of Cyprus.

In 1299–1300, the Cypriots sought to retake the Syrian port city of Tortosa, by setting up a staging area on Ruad, two miles (3 km) off the coast of Tortosa. The plans were to coordinate an offensive between the forces of the Crusaders, and those of the Ilkhanate (Mongol Persia). However, though the Crusaders successfully established a bridgehead on the island, the Mongols did not arrive, and the Crusaders were forced to withdraw the bulk of their forces to Cyprus. The Knights Templar set up a permanent garrison on the island in 1300, but the Mamluks besieged and captured Ruad in 1302. With the loss of the island, the Crusaders lost their last foothold in the Holy Land. Attempts at other Crusades continued for centuries, but the Europeans were never again able to occupy any territory in the Holy Land until the 20th century, during the events of World War I.