On 20 October 1280, the Mongols took Aleppo, pillaging the markets and burning the mosques. The Muslim inhabitants fled for Damascus, where the Mamluk leader Qalawun assembled his forces.

On 29 October 1281, the two armies met south of Homs, a city in western Syria. In a pitched battle, the Armenians, Georgians and Oirats under King Leo II and Mongol generals routed and scattered the Mamluk left flank, but the Mamluks personally led by Sultan Qalawun destroyed the Mongol centre. Möngke Temur was wounded and fled, followed by his disorganized army. However, Qalawun chose to not pursue the defeated enemy, and the Armenian-Georgian auxiliaries of the Mongols managed to withdraw safely. The following year, Abaqa died and his successor, Tekuder, reversed his policy towards the Mamluks. He converted to Islam and forged an alliance with the Mamluk sultan.