Henry VI of England lost his mental capacity in late 1453, which led to the outbreak of the Wars of the Roses in England. Some have speculated that learning of the defeat at Castillon led to his mental collapse. The English Crown lost all its continental possessions except for the Pale of Calais, which was the last English possession in mainland France, and the Channel Islands, historically part of the Duchy of Normandy and thus of the Kingdom of France. Calais was lost in 1558.

The Treaty of Picquigny(1475) formally ended the Hundred Years' War with Edward renouncing his claim to the throne of France. Louis XI was to pay Edward IV 75,000 crowns upfront, essentially a bribe to return to England and not take up arms to pursue his claim to the French throne. He would then receive a yearly pension thereafter of 50,000 crowns. Also the King of France was to ransom the deposed English queen, Margaret of Anjou, who was in Edward's custody, with 50,000 crowns. It also included pensions to many of Edward's lords.