The Comanche–Mexico Wars was the Mexican theater of the Comanche Wars, a series of conflicts from 1821 to 1870. The Comanche and their Kiowa and Kiowa Apache allies carried out large-scale raids hundreds of miles deep into Mexico killing thousands of people and stealing hundreds of thousands of cattle and horses. The Comanche raids were sparked by the declining military capability of Mexico during the turbulent years after it gained independence in 1821, as well as a large and growing market in the United States for stolen Mexican horses and cattle.

When the US Army invaded northern Mexico in 1846 during the Mexican–American War, the region was devastated. The largest Comanche raids into Mexico took place from 1840 to the mid-1850s, after which they declined in size and intensity. The Comanche were finally defeated by the United States Army in 1875 and forced onto a reservation.