The war in Italy primarily involved the Spanish-ruled Duchies of Milan and Mantua, considered essential to the security of Austria's southern borders. In 1701, French troops occupied both cities and Victor Amadeus II, Duke of Savoy, allied with France, his daughter Maria Luisa marrying Philip V. In May 1701, an Imperial army under Prince Eugene of Savoy moved into Northern Italy; by February 1702, victories at Carpi, Chiari and Cremona forced the French behind the Adda river.

A combined Savoyard-Imperial attack on the French base of Toulon planned for April was postponed when Imperial troops were diverted to seize the Spanish Bourbon Kingdom of Naples. By the time they besieged Toulon in August, the French were too strong, and they were forced to withdraw. By the end of 1707, fighting in Italy ceased, apart from small-scale attempts by Victor Amadeus to recover Nice and Savoy.