During the 16th century the spice trade was extremely lucrative, but the Portuguese Empire had a stranglehold on the source of the spices, Indonesia. For a time, the merchants of the Netherlands were content to accept this and buy all of their spice in Lisbon, Portugal, as they could still make a decent profit by reselling it throughout Europe. However, in the 1590s Spain, which was at war with the Netherlands, was in a dynastic union with Portugal, thus making continued trade practically impossible.^[29] This was intolerable to the Dutch who would have been glad to circumvent the Portuguese monopoly and go straight to Indonesia

The First Dutch Expedition to East Indies was an expedition that took place from 1595 to 1597. It was instrumental in opening up the Indonesian spice trade to the merchants that eventually formed the Dutch East India Company, and marked the end of the Portuguese Empire's dominance in the region.