The siege of Eretria took place in 490 BCE, during the first Persian invasion of Greece. The city of Eretria, on Euboea, was besieged by a strong Persian force under the command of Datis and Artaphernes. Reaching Euboea in mid-summer after a successful campaign in the Aegean, the Persians proceeded to put Eretria under siege. The siege lasted six days before a fifth column of Eretrian nobles betrayed the city to the Persians. The city was plundered, and the population was deported to the village Ardericca in Susiana near the Persian capital.

After Eretria, the Persian force sailed for Athens, landing at the bay of Marathon. An Athenian army marched to meet them, and won a famous victory at the Battle of Marathon, thereby ending the first Persian invasion.