A fragile peace was broken in 1467, when Ibrahim of Kazan came to the throne and Ivan III of Russia supported the claims of his ally or vassal Qasim Khan. Ivan's army sailed down the Volga, with their eyes fixed on Kazan, but autumn rains and rasputitsa ("quagmire season") hindered the progress of Russian forces. The campaign fell apart for lack of unity of purpose and military capability.

In 1469, a much stronger army was raised and, sailing down the Volga and the Oka, linked up in Nizhny Novgorod. The Russians marched downstream and ravaged the neighbourhood of Kazan. After negotiations were broken, the Tatars clashed with the Russians in two bloody but indecisive battles.

In autumn 1469 Ivan III launched a third invasion of the khanate. The Russian commander, Prince Daniil Kholmsky, besieged Kazan, cut off water supplies, and compelled Ibrahim to surrender. Under the terms of the peace settlement, the Tatars set free all the ethnic Christian Russians they had enslaved in the forty previous years.