The Britons had appointed Cassivellaunus, a warlord from north of the Thames, to lead their combined forces. Cassivellaunus realised he could not defeat Caesar in a pitched battle. Disbanding the majority of his force and relying on the mobility of his 4,000 chariots and superior knowledge of the terrain, he used guerrilla tactics to slow the Roman advance. By the time Caesar reached the Thames, the one fordable place available to him had been fortified with sharpened stakes, both on the shore and under the water, and the far bank was defended.

The Trinovantes, whom Caesar describes as the most powerful tribe in the region, and who had recently suffered at Cassivellaunus' hands, sent ambassadors, promising him aid and provisions. Mandubracius, who had accompanied Caesar, was restored as their king, and the Trinovantes provided grain and hostages. Five further tribes, the Cenimagni, Segontiaci, Ancalites, Bibroci and Cassi, surrendered to Caesar, and revealed to him the location of Cassivellaunus' stronghold, possibly the hill fort at Wheathampstead, which he proceeded to put under siege.

Cassivellaunus sent word to his allies in Kent, Cingetorix, Carvilius, Taximagulus and Segovax, described as the "four kings of Cantium", to stage a diversionary attack on the Roman beach-head to draw Caesar off, but this attack failed, and Cassivellaunus sent ambassadors to negotiate a surrender. Caesar was eager to return to Gaul for the winter due to growing unrest there, and an agreement was mediated by Commius. Cassivellaunus gave hostages, agreed an annual tribute, and undertook not to make war against Mandubracius or the Trinovantes. Caesar wrote to Cicero on 26 September, confirming the result of the campaign, with hostages but no booty taken, and that his army was about to return to Gaul. He then left, leaving not a single Roman soldier in Britain to enforce his settlement. Whether the tribute was ever paid is unknown.