The Battle of Panormus was fought in Sicily in 250 BCE during the First Punic War between a Roman army led by Lucius Caecilius Metellus and a Carthaginian force led by Hasdrubal, son of Hanno. The Roman force of two legions defending the city of Panormus defeated the much larger Carthaginian army of 30,000 men and between 60 and 142 war elephants.

The war had commenced in 264 BCE with Carthage in control of much of Sicily, where most of the fighting took place. In 256–255 BCE the Romans attempted to strike at the city of Carthage in North Africa, but suffered a heavy defeat by a Carthaginian army strong in cavalry and elephants. When the focus of the war returned to Sicily, the Romans captured the large and important city of Panormus in 254 BCE. Thereafter they avoided battle for fear of the war elephants which the Carthaginians had shipped to Sicily. In late summer 250 BCE Hasdrubal led out his army to devastate the crops of the cities of Rome's allies. The Romans withdrew to Panormus and Hasdrubal pressed on to the city walls.

Once he arrived in Panormus, Metellus turned to fight, countering the elephants with a hail of javelins from earthworks dug near the walls. Under this missile fire the elephants panicked and fled through the Carthaginian infantry. The Roman heavy infantry then charged the Carthaginian left flank, which broke, along with the rest of the Carthaginians. The elephants were captured and later slaughtered in the Circus Maximus. This was the last significant land battle of the war, which ended nine years later in a Roman victory.