A crisis erupted in Little Rock, Arkansas, when Governor of Arkansas Orval Faubus called out the National Guard on September 4 to prevent entry to the nine African-American students who had sued for the right to attend an integrated school, Little Rock Central High School. Under the guidance of Daisy Bates, the nine students had been chosen to attend Central High because of their excellent grades. Called the "Little Rock Nine", they were Ernest Green, Elizabeth Eckford , Jefferson Thomas, Terrence Roberts, Carlotta Walls LaNier, Minnijean Brown, Gloria Ray Karlmark, Thelma Mothershed, and Melba Pattillo Beals.

On the first day of school, 15-year-old Elizabeth Eckford was the only one of the nine students who showed up because she did not receive the phone call about the danger of going to school. A photo was taken of Eckford being harassed by white protesters outside the school, and the police had to take her away in a patrol car for her protection. Afterwards, the nine students had to carpool to school and be escorted by military personnel in jeeps.

Faubus was not a proclaimed segregationist. The Arkansas Democratic Party, which then controlled politics in the state, put significant pressure on Faubus after he had indicated he would investigate bringing Arkansas into compliance with the Brown decision. Faubus then took his stand against integration and against the Federal court ruling. Faubus' resistance received the attention of President Dwight D. Eisenhower, who was determined to enforce the orders of the Federal courts. Critics had charged he was lukewarm, at best, on the goal of desegregation of public schools. But, Eisenhower federalized the National Guard in Arkansas and ordered them to return to their barracks. Eisenhower deployed elements of the 101st Airborne Division to Little Rock to protect the students.

The students attended high school under harsh conditions. They had to pass through a gauntlet of spitting, jeering whites to arrive at school on their first day, and to put up with harassment from other students for the rest of the year. Although federal troops escorted the students between classes, the students were teased and even attacked by white students when the soldiers were not around. One of the Little Rock Nine, Minnijean Brown, was suspended for spilling a bowl of chili on the head of a white student who was harassing her in the school lunch line. Later, she was expelled for verbally abusing a white female student.