The last of the Roman–Persian Wars ended in 628, after Heraclius concluded a successful campaign against the Persians in Mesopotamia. At the same time, Muhammad united the Arabs under the banner of Islam. After his death in 632, Abu Bakr succeeded him as the first Rashidun Caliph. Suppressing several internal revolts, Abu Bakr sought to expand the empire beyond the confines of the Arabian Peninsula.

The Muslim conquest of the Levant occurred in the first half of the 7th century. This was the conquest of the region known as the Levant or Shaam, later to become the Islamic Province of Bilad al-Sham, as part of the Islamic conquests. Arab Muslim forces had appeared on the southern borders even before the death of Muhammad in 632, resulting in the Battle of Mu'tah in 629, but the real conquest began in 634 under his successors, the Rashidun Caliphs Abu Bakr and Umar ibn Khattab, with Khalid ibn al-Walid as their most important military leader.