The Byzantine army, composed of the survivors of Yarmouk and other Syrian campaigns, was defeated, retreating to Antioch, whereupon the Muslims besieged the city. Having little hope of help from the Emperor, Antioch surrendered on 30 October, on the condition that all Byzantine troops would be given safe passage to Constantinople.

Emperor Heraclius had already left Antioch for Edessa before the Muslims arrived. He then arranged for the necessary defenses in Jazirah and left for Constantinople. On the way, he had a narrow escape when Khalid, who had just captured Marash, was heading south towards Manbij. Heraclius hastily took the mountainous path and, on passing through the Cilician gates, is reported to have said, "Farewell, a long farewell to Syria, my fair province. Thou art an infidel's (enemy's) now. Peace be with you, O, Syria – what a beautiful land you will be for the enemy hands."