The Heraclius' campaign of 622, erroneously also known as the Battle of Issus, was a major campaign in the Byzantine–Sassanid War of 602–628 by emperor Heraclius that culminated in a crushing Byzantine victory in Anatolia.

In 622, the Byzantine emperor Heraclius, was ready to mount a counter-offensive against the Sassanid Persians who had overrun most of the eastern provinces of the Byzantine Empire. Heraclius won a crushing victory over Shahrbaraz somewhere in Cappadocia. The key factor was Heraclius' discovery of hidden Persian forces in ambush and responding to this ambush by feigning retreat during the battle. The Persians left their cover to chase the Byzantines, whereupon Heraclius' elite Optimatoi assaulted the chasing Persians, causing them to flee.